Here’s the American English translation of the provided text:
—
A multinational study led by the Hospital del Mar Research Institute has revealed the crucial role of amino acids in regulating cellular responses to drugs. This finding, published in the journal Nature Communications, suggests that amino acids act as building blocks that allow cells to communicate internally, facilitating a more efficient regulation of their responses.
The research focused on the cannabinoid receptor type 2 (CB2), a key protein in the human immune system. This receptor, which belongs to the family of G protein-coupled receptors (GPCRs), is the target of approximately one-third of approved medications used to treat a variety of conditions, ranging from cardiovascular diseases to mental disorders.
To conduct the study, the scientists employed computer simulations, laboratory experimentation, and artificial intelligence tools to analyze the interaction of all the amino acids in the receptor. Dr. Jana Selent, the coordinator of the research group, emphasized the importance of understanding how these building blocks operate within an extensive network to activate specific responses. This could facilitate the design of more precise drugs aimed at maximizing treatment efficacy while minimizing unwanted side effects.
The findings indicate that amino acids do not act in isolation; instead, they continuously interact in a dynamic network that modulates cellular responses to various stimuli, including drugs and environmental changes. This knowledge has the potential to be fundamental in developing more specific and careful treatments, especially for diseases whose current treatments are known to cause undesirable side effects.
The data generated from this research, as well as the tools used, have been publicly shared through the GPCRMD platform, with the aim of encouraging other researchers to utilize this valuable information in future studies.
via: MiMub in Spanish
